How to incorporate multiple markers in clinical trials

How to incorporate clinical experience into evidence-based medicine.

Evidence-based medicine (EBM) represents a paradigm change in the way in which medicine is practiced. On one level, evidence-based medicine is a formalism for integrating “research evidence with clinical expertise and patient values.”5 It is not intended to supplant clinical experience, but rather to augment and strengthen it. There has been a concern voiced within the neurosurgical community t...

Extending taxonomic visualisation to incorporate synonymy and structural markers

The visualisation of taxonomic hierarchies has evolved from indented lists of names to techniques that can display thousands of nodes and onto hundreds of thousands of nodes over multiple taxonomies. However, challenges remain within multiple hierarchy visualisation, and for taxonomic hierarchy visualisation in particular. Firstly, at present, there is no support for handling specific taxonomic...

How to interpret figures in reports of clinical trials.

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

How to Incorporate Negation in a Prolog Compiler

Knowledge representation based applications require a more complete set of capabilities than those ooered by conventional Prolog compilers. Negation is, probably, the most important one. The inclusion of negation among the logical facilities of LP has been a very active area of research, and several techniques have been proposed. However, the negation capabilities accepted by current Prolog com...